Carboxylation of C−H Bonds Using N-Heterocyclic Carbene Gold(I) Complexes
Ine I. F. Boogaerts and Steven P. Nolan*
J. Am. Chem. Soc., Article ASAP
DOI: 10.1021/ja103429q
Publication Date (Web): June 11, 2010
http://pubs.acs.org/doi/abs/10.1021/ja103429q
^o^: An impressive piece of work by Nolan. They addressed an extremely important concept of functionalizing C-H bonds on heterocycles, in which chemists in pharma industry will definitely be enthusiatic about. The great thing about this piece of chemistry is that the reactions in question can be done in AIR - no inert atmosphere required. An interesting aspect is the hydroxyl (OH) ligand on the gold catalyst, which have drawn parellels in the field of Rh catalysed conjugate additions (e.g. Hayashi et. al.). It would be exciting to see if this aspect have any implications on the chemistry itself , for example, what will be the effect of WATER on the reaction profile? Clearly the next step to assess this methodology is the functionalizations of more useful chemical entities onto the heterocyclic rings.
P.S. It would be nice if they can use dry ice as the source of CO2...
by Ed Law ^o^ - 11/6/2010
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