Taken from Reference (1) - from the JACS Website.
What a fascinating bio-organometallic achievment. The star here is a Ruthenium complex, which is known as a Carbon monoxide releasing molecules (CORM) due to its ability to lose (thus deliver) a CO molecule (to set the record straight a glycinate ligand and a chloride ion are also liberated) and the result is a RuII(CO)2 intermediate. This will in turn react with the protein lyzozyme to form a complex, for which its structure was determined by crystallography and also with a number of cutting-edge spectroscopic techniques (including of course LC-MS). CORMs are interesting because they have demonstrated therapeutic potentials for future drugs.
Reference:
(1) CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru(II) Dicarbonyl−Lysozyme Complex
Teresa Santos-Silva, Abhik Mukhopadhyay, Joo D. Seixas, Gonalo J. L. Bernardes, Carlos C. Romo, and Maria J. Romo
J. Am. Chem. Soc., Article ASAP
Publication Date (Web): January 4, 2011
DOI: 10.1021/ja108820s
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